Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …

Tissue physical properties depend on the cells that make the tissue and also seem to be
affected by tissue use. For example, muscle, cartilage, and bone, when suitably exercised …

Cancer metastasis, ie, the spreading of tumor cells from the primary tumor to distant organs,
is responsible for the vast majority of cancer deaths. In the process, cancer cells migrate …

Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C,
cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other …

The principles of engineering and physics have been applied to oncology for nearly 50
years. Engineers and physical scientists have made contributions to all aspects of cancer …

Mammalian cells frequently migrate through tight spaces during normal embryogenesis,
wound healing, diapedesis, or in pathological situations such as metastasis. Nuclear size …

Migration through micron-size constrictions has been seen to rupture the nucleus, release
nuclear-localized GFP, and cause localized accumulations of ectopic 53BP1—a DNA repair …