Current studies of human gut microbiome usually do not consider the special functional role
of transient microbiota, although some of its members remain in the host for a long time and …

SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange
factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins …

Background: Small cell lung cancer (SCLC) is an extremely aggressive cancer type with a
patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal lung disease
with unknown etiology and poor prognosis. IPF patients die within 2 years after diagnosis …

To deliver therapeutic proteins into a living body, it is important to maintain their target
activity in the gastrointestinal tract after oral administration. Secreted ribonuclease from …

Ribonucleases (RNases) are a large number of enzymes gathered into different bacterial or
eukaryotic superfamilies. Bovine pancreatic RNase A, bovine seminal BS-RNase, human …

Objective: Small GTPase is an important molecular switch that plays an important role in
numerous signaling transduction pathways, the aim is to explore its binary classification …

Among the numerous oncogenes involved in human cancers, KRAS represents the most
studied and best characterized cancer-related genes. Several therapeutic strategies …

Many ribonucleases (RNases) are considered as promising tools for antitumor therapy
because of their selective cytotoxicity toward cancer cells. Binase, the RNase from Bacillus …

Recently, pancreatic RNase A was shown to inhibit tumor and metastasis growth that
accompanied by global alteration of miRNA profiles in the blood and tumor tissue (Mironova …