Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

The hypothalamus plays a key role in coordinating fundamental body functions. Despite
recent progress in single-cell technologies, a unified catalog and molecular characterization …

Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers
glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic …

Obesity is among the most common and costly chronic disorders worldwide. Estimates
suggest that in the United States obesity affects one-third of adults, accounts for up to one …

Neuronal cell types are the nodes of neural circuits that determine the flow of information
within the brain. Neuronal morphology, especially the shape of the axonal arbor, provides …

The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown …

Tremendous progress has been made since Neuron published our Primer on genetic
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …

Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …

Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …