With the aging population, prevalence of neurodegenerative diseases is increasing, thus
placing a growing burden on individuals and the whole society. However, individual rates of …

Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

Automatic segmentation in MR brain images is important for quantitative analysis in large-
scale studies with images acquired at all ages. This paper presents a method for the …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

The disparity between the chronological age of an individual and their brain-age measured
based on biological information has the potential to offer clinically relevant biomarkers of …

Human cortex appears to thin during childhood development. However, the underlying
microstructural mechanisms are unknown. Using functional magnetic resonance imaging …

Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain
asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the …

What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

Little is still known about the neuroanatomical substrates related to changes in specific
cognitive abilities in the course of healthy aging, and the existing evidence is predominantly …

Many studies of the human brain have explored the relationship between cortical thickness
and cognition, phenotype, or disease. Due to the subjectivity and time requirements in …