The β Subunit of Voltage-Gated Ca2+ Channels
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …
contraction, neuronal communication, hormone release, cell division, and gene …
L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function
F Hofmann, V Flockerzi, S Kahl… - Physiological …, 2014 - journals.physiology.org
The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …
essential for some aspects of CNS function, cardiac and smooth muscle contractility …
Adrenergic regulation of calcium channels in the heart
Each heartbeat is initiated by the action potential, an electrical signal that depolarizes the
plasma membrane and activates a cycle of calcium influx via voltage-gated calcium …
plasma membrane and activates a cycle of calcium influx via voltage-gated calcium …
EMC chaperone–CaV structure reveals an ion channel assembly intermediate
Voltage-gated ion channels (VGICs) comprise multiple structural units, the assembly of
which is required for function,. Structural understanding of how VGIC subunits assemble and …
which is required for function,. Structural understanding of how VGIC subunits assemble and …
Voltage-gated calcium channels in nonexcitable tissues
The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy
syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted …
syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted …
[HTML][HTML] Regulation of CaV2 calcium channels by G protein coupled receptors
Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …
[HTML][HTML] Structure and function of the β subunit of voltage-gated Ca2+ channels
The voltage-gated Ca2+ channel β subunit (Cavβ) is a cytosolic auxiliary subunit that plays
an essential role in regulating the surface expression and gating properties of high-voltage …
an essential role in regulating the surface expression and gating properties of high-voltage …
Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop
A Papa, J Kushner, JA Hennessey… - Circulation …, 2021 - Am Heart Assoc
Rationale: Changing activity of cardiac CaV1. 2 channels under basal conditions, during
sympathetic activation, and in heart failure is a major determinant of cardiac physiology and …
sympathetic activation, and in heart failure is a major determinant of cardiac physiology and …
[HTML][HTML] Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels
Voltage-gated sodium channels (Na V s) are central elements of cellular excitation.
Notwithstanding advances from recent bacterial Na V (BacNa V) structures, key questions …
Notwithstanding advances from recent bacterial Na V (BacNa V) structures, key questions …
Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response
A Papa, SI Zakharov, AN Katchman… - Nature cardiovascular …, 2022 - nature.com
Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and
contractile force. In the present study, we uncover the primary mechanism underlying the …
contractile force. In the present study, we uncover the primary mechanism underlying the …