Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …

BACKGROUND: Early-life emotional stress may be associated with affective and cognitive
disorders later in life, yet satisfactory animal models for studying the underlying mechanisms …

One of the conundrums in today's stress research is why some individuals flourish and
others perish under similar stressful conditions. It is recognized that this individual variability …

Early life stress increases the risk for develo** stress-related pathologies later in life.
Recent studies in rats suggest that mild early life stress, rather than being overall …

de Kloet ER, Sibug RM, Helmerhost FM, Schmidt M. Stress, genes and the mechanism of
programming the brain for later life. Neurosci Biobehav Rev XXX–XXX, 2005 adverse …

Stress exposure activates the HPA-axis and results in the release of corticosteroids which
bind to two receptor types in the brain: the mineralocorticoid receptor (MR) and the …

BACKGROUND: Adverse life events occurring early in development may alter the correct
program of brain maturation and render the organism more vulnerable to psychiatric …

Neurogenesis and apoptosis in the hippocampal dentate gyrus (DG) occur during
development and adulthood. However, little is known about how these two processes relate …

BACKGROUND: High coincidence of childhood abuse, major depressive disorder (MDD),
and posttraumatic stress disorder (PTSD) has been reported in patients with borderline …