New perspectives in diabetic neuropathy

SA Eid, AE Rumora, B Beirowski, DL Bennett, J Hur… - Neuron, 2023 - cell.com
Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy

G Sloan, D Selvarajah, S Tesfaye - Nature Reviews Endocrinology, 2021 - nature.com
Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

S Eid, KM Sas, SF Abcouwer, EL Feldman, TW Gardner… - Diabetologia, 2019 - Springer
Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to
diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both …

Diabetic neuropathy

EL Feldman, BC Callaghan, R Pop-Busui… - Nature reviews Disease …, 2019 - nature.com
The global epidemic of prediabetes and diabetes has led to a corresponding epidemic of
complications of these disorders. The most prevalent complication is neuropathy, of which …

Metabolic syndrome and peripheral neuropathy

M Kazamel, AM Stino, AG Smith - Muscle & Nerve, 2021 - Wiley Online Library
Diabetic peripheral neuropathy and metabolic syndrome (MetS) are both global health
challenges with well‐established diagnostic criteria and significant impacts on quality of life …

Diabetic neuropathy and neuropathic pain: a (con) fusion of pathogenic mechanisms?

NA Calcutt - Pain, 2020 - journals.lww.com
Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy

Y Liu, S Shao, H Guo - Life sciences, 2020 - Elsevier
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that
affects approximately half of patients with diabetes. Current treatment regimens cannot treat …

Evolving concepts on the role of dyslipidemia, bioenergetics, and inflammation in the pathogenesis and treatment of diabetic peripheral neuropathy

AM Stino, AE Rumora, B Kim… - Journal of the Peripheral …, 2020 - Wiley Online Library
Diabetic peripheral neuropathy (DPN) is one of the most widespread and disabling
neurological conditions, accounting for half of all neuropathy cases worldwide. Despite its …

The emerging role of dyslipidemia in diabetic microvascular complications

MG Savelieff, BC Callaghan… - Current Opinion in …, 2020 - journals.lww.com
Dyslipidemia is an emerging mechanism in microvascular complications in T2D. Elucidating
the molecular pathomechanisms may pinpoint potential lipid-centric treatments …

Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes

PD O'Brien, K Guo, SA Eid… - Disease models & …, 2020 - journals.biologists.com
Peripheral neuropathy (PN) is a complication of prediabetes and type 2 diabetes (T2D).
Increasing evidence suggests that factors besides hyperglycaemia contribute to PN …