Epigenetics is the epi-information beyond the DNA sequence that can be inherited from
parents to offspring. From years of studies, people have found that histone modifications …

Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Obesity is considered an important factor for many chronic diseases, including diabetes,
cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an …

Fibrosis is responsible for chronic progressive kidney failure, which is present in a large
number of adults in the developed world. It is increasingly appreciated that acute kidney …

Histone proteins and the nucleosomes they form with DNA are the fundamental building
blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often …

Considerable progress has been made in identifying signaling pathways that direct the
differentiation of human pluripotent stem cells (hPSCs) into specialized cell types, including …

Diffuse gliomas are up till now graded based upon morphology. Recent findings indicate
that isocitrate dehydrogenase (IDH) mutation status defines biologically distinct groups of …

The organization of chromatin into higher-order structures influences chromosome function
and epigenetic gene regulation. Higher-order chromatin has been proposed to be nucleated …

Understanding the molecular mechanisms that promote successful tissue regeneration is
critical for continued advancements in regenerative medicine. Vertebrate amphibian …

To enable arrayed or pooled loss-of-function screens in a wide range of mammalian cell
types, including primary and nondividing cells, we are develo** lentiviral short hairpin …