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Advances in acute ischemic stroke treatment: Current status and future directions
The management of acute ischemic stroke has undergone a paradigm shift in the past
decade. This has been spearheaded by the emergence of endovascular thrombectomy …
decade. This has been spearheaded by the emergence of endovascular thrombectomy …
Contemporary neuroprotection strategies during cardiac surgery: state of the art review
Open-heart surgery is the leading cause of neuronal injury in the perioperative state, with
some patients complicating with cerebrovascular accidents and delirium. Neurological …
some patients complicating with cerebrovascular accidents and delirium. Neurological …
Thrombectomy for M2 occlusions: predictors of successful and futile recanalization
BACKGROUND: Patient-specific factors associated with successful recanalization in
mechanical thrombectomy (MT) have been evaluated for acute ischemic stroke with large …
mechanical thrombectomy (MT) have been evaluated for acute ischemic stroke with large …
Association of infarct topography and outcome after endovascular thrombectomy in patients with acute ischemic stroke
Background and Objectives The care of patients with large vessel occlusion (LVO) stroke
has been revolutionized by endovascular thrombectomy (EVT). While EVT has a large effect …
has been revolutionized by endovascular thrombectomy (EVT). While EVT has a large effect …
What is a meaningful difference when using infarct volume as the primary outcome?: results from the HERMES database
BACKGROUND: Ischemic stroke lesion volume at follow-up is an important surrogate
outcome for acute stroke trials. We aimed to assess which differences in 48-hour lesion …
outcome for acute stroke trials. We aimed to assess which differences in 48-hour lesion …
How can imaging in acute ischemic stroke help us to understand tissue fate in the era of endovascular treatment and cerebroprotection?
The most frequent cause of ischemic stroke is occlusion of an intracranial or cervical artery,
disturbing brain tissue perfusion. Decrease in cerebral perfusion below key thresholds …
disturbing brain tissue perfusion. Decrease in cerebral perfusion below key thresholds …
Effect of hemoglobin and blood glucose levels on CT perfusion ischemic core estimation: a post hoc analysis of the ESCAPE-NA1 trial
Background and Objectives CT perfusion (CTP) maps can estimate the ischemic core in
acute ischemic stroke based on distinctive cerebral blood flow thresholds. However …
acute ischemic stroke based on distinctive cerebral blood flow thresholds. However …
Infarct evolution on MR-DWI after thrombectomy in acute stroke patients randomized to nerinetide or placebo: the REPERFUSE-NA1 Study
J Fladt, J Guo, JL Specht, M Wang, LL Chan… - Neurology, 2024 - neurology.org
Background and Objectives The neuroprotectant nerinetide has shown promise in reducing
infarct volumes in primate models of ischemia reperfusion. We hypothesized that early …
infarct volumes in primate models of ischemia reperfusion. We hypothesized that early …
[HTML][HTML] Infarcts due to large vessel occlusions continue to grow despite near-complete reperfusion after endovascular treatment
Background and Purpose Infarcts in acute ischemic stroke (AIS) patients may continue to
grow even after reperfusion, due to mechanisms such as microvascular obstruction and …
grow even after reperfusion, due to mechanisms such as microvascular obstruction and …
Influence of Infarct Morphology and Patterns on Cognitive Outcomes After Endovascular Thrombectomy
BACKGROUND: To assess the association of qualitative and quantitative infarct
characteristics and 3 cognitive outcome tests, namely the Montreal Cognitive Assessment …
characteristics and 3 cognitive outcome tests, namely the Montreal Cognitive Assessment …