Bacterial culture was the first method used to describe the human microbiota, but this
method is considered outdated by many researchers. Metagenomics studies have since …

For the past 20 years, the Clusters of Orthologous Genes (COG) database had been a
popular tool for microbial genome annotation and comparative genomics. Initially created for …

NLM's conserved domain database (CDD) is a collection of protein domain and protein
family models constructed as multiple sequence alignments. Its main purpose is to provide …

The increasing application of meta‐omics approaches to investigate the structure, function,
and intercellular interactions of microbial communities has led to a surge in available data …

Abstract The Clusters of Orthologous Genes (COG) database, also referred to as the
Clusters of Orthologous Groups of proteins, was created in 1997 and went through several …

Abstract As NLM's Conserved Domain Database (CDD) enters its 20th year of operations as
a publicly available resource, CDD curation staff continues to develop hierarchical …

Abstract NCBI's Conserved Domain Database (CDD) aims at annotating biomolecular
sequences with the location of evolutionarily conserved protein domain footprints, and …

NCBI's CDD, the Conserved Domain Database, enters its 15th year as a public resource for
the annotation of proteins with the location of conserved domain footprints. Going forward …

Recent technological advances have opened unprecedented opportunities for large-scale
sequencing and analysis of populations of pathogenic species in disease outbreaks, as well …

Microbial genome sequencing projects produce numerous sequences of deduced proteins,
only a small fraction of which have been or will ever be studied experimentally. This leaves …