The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …
antibiotics are becoming less effective against these bacteria, such that we risk entering a …
Chemically modified and conjugated antimicrobial peptides against superbugs
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
Versatile antibacterial materials: an emerging arsenal for combatting bacterial pathogens
Antibacterial materials that prevent bacterial infections and mitigate bacterial virulence have
attracted great scientific interests. In recent decades, the bactericidal polymers have been …
attracted great scientific interests. In recent decades, the bactericidal polymers have been …
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …
Engineering precise sequence-defined polymers for advanced functions
Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …
Advances in development of antimicrobial peptidomimetics as potential drugs
The rapid emergence of multidrug-resistant pathogens has evolved into a global health
problem as current treatment options are failing for infections caused by pan-resistant …
problem as current treatment options are failing for infections caused by pan-resistant …
Emerging trends in macromolecular antimicrobials to fight multi-drug-resistant infections
Synthetic macromolecular antimicrobials are a highly promising class of therapeutics with
immense potential for combating multidrug resistant microbes. In contrast to conventional …
immense potential for combating multidrug resistant microbes. In contrast to conventional …
Small molecular antibacterial peptoid mimics: the simpler the better!
The emergence of multidrug resistant bacteria compounded by the depleting arsenal of
antibiotics has accelerated efforts toward development of antibiotics with novel mechanisms …
antibiotics has accelerated efforts toward development of antibiotics with novel mechanisms …
Membrane‐active small molecules: designs inspired by antimicrobial peptides
Infectious diseases continue to be one of the major contributors to human morbidity. The
rapid rate at which pathogenic microorganisms have developed resistance against frontline …
rapid rate at which pathogenic microorganisms have developed resistance against frontline …
Crystal Engineering of a Microporous, Catalytically Active fcu Topology MOF Using a Custom‐Designed Metalloporphyrin Linker
A major driving force behind the recent surge of interest in metal–organic frameworks
(MOFs)[1] lies with their amenability to design using crystal engineering [2a–d] strategies. In …
(MOFs)[1] lies with their amenability to design using crystal engineering [2a–d] strategies. In …