Self-assembling nucleic acid nanostructures functionalized with aptamers
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …
would allow artificial biopolymer complexes to self-assemble and function similarly to the …
Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression
Nanotechnology offers many benefits, and here we report an advantage of applying RNA
nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to …
nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to …
Advancement of the emerging field of RNA nanotechnology
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …
RNA interference-based therapy and its delivery systems
X Chen, LS Mangala, C Rodriguez-Aguayo… - Cancer and Metastasis …, 2018 - Springer
RNA interference (RNAi) is considered a highly specific approach for gene silencing and
holds tremendous potential for treatment of various pathologic conditions such as …
holds tremendous potential for treatment of various pathologic conditions such as …
Delivery of anti-miRNA for triple-negative breast cancer therapy using RNA nanoparticles targeting stem cell marker CD133
H Yin, G **
Folate (FA) receptor is a cell surface glycoprotein overexpressed on many cancer cells. It is
a high affinity ligand for cancer cell targeting. However, delivery of siRNA directly through …
a high affinity ligand for cancer cell targeting. However, delivery of siRNA directly through …
Opportunities, barriers, and a strategy for overcoming translational challenges to therapeutic nucleic acid nanotechnology
606Recent clinical successes using therapeutic nucleic acids (TNAs) have accelerated the
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …
Structure and composition define immunorecognition of nucleic acid nanoparticles
E Hong, JR Halman, AB Shah… - Therapeutic RNA …, 2021 - taylorfrancis.com
912Nucleic acid nanoparticles (NANPs) have evolved as a new class of therapeutics with
the potential to detect and treat diseases. Despite tremendous advancements in NANP …
the potential to detect and treat diseases. Despite tremendous advancements in NANP …