The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Recent advances in single-cell sequencing technologies offer an opportunity to explore cell–
cell communication in tissues systematically and with reduced bias. A key challenge is …

Understanding global communications among cells requires accurate representation of cell-
cell signaling links and effective systems-level analyses of those links. We construct a …

The development of single-cell multimodal assays provides a powerful tool for investigating
multiple dimensions of cellular heterogeneity, enabling new insights into development …

Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

The development of single-cell multi-omics technology has greatly enhanced our
understanding of biology, and in parallel, numerous algorithms have been proposed to …

Here, we review single-cell sequencing techniques for individual and multiomics profiling in
single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic …

An explosion in single-cell technologies has revealed a previously underappreciated
heterogeneity of cell types and novel cell-state associations with sex, disease, development …

Single-cell multiomics data continues to grow at an unprecedented pace. Although several
methods have demonstrated promising results in integrating several data modalities from …

Cell–cell communication is a fundamental process that shapes biological tissue. Historically,
studies of cell–cell communication have been feasible for one or two cell types and a few …