Precise nanomedicine has been extensively explored for efficient cancer imaging and
targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and …

Biocatalytic cascades guide complex, efficient and selective intracellular transformations.
These unique features originate from the spatial organization of the biocatalysts in confined …

MicroRNA (miR)‐based therapy shows strong potential; however, structural limitations pose
a challenge in fully exploiting its biomedical functionality. Tetrahedral framework DNA (tFNA) …

The in vivo optical imaging of RNA biomarkers of inflammation is hindered by low signal-to-
background ratios, owing to non-specific signal amplification in healthy tissues. Here we …

The primer-guided entropy-driven high-throughput evolution of the DNA-based
constitutional dynamic network, CDN, is introduced. The entropy gain associated with the …

The wide extracellular‐intracellular distribution of microRNA requires the on‐site, robust and
efficient activation of catalytic DNA circuits inside live cells. Herein, we develop an efficient …

Synthetic catalytic DNA circuits have been recognized as a promising signal amplification
toolbox for sensitive intracellular imaging, yet their selectivity and efficiency are always …

Sensitive and accurate analysis of low‐concentration of tumor‐derived exosomes (Exos) in
biofluids is essential for noninvasive cancer diagnosis but is still challenging due to the lack …

In virtue of the inherent molecular recognition and programmability, DNA has recently
become the most promising for high-performance biosensors. The rationally engineered …

In recent years, DNA has been widely noted as a kind of material that can be used to
construct building blocks for biosensing, in vivo imaging, drug development, and disease …