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[HTML][HTML] Cells, pathways, and models in dyskinesia research
Abstract L-DOPA-induced dyskinesia (LID) is the most common form of hyperkinetic
movement disorder resulting from altered information processing in the cortico-basal ganglia …
movement disorder resulting from altered information processing in the cortico-basal ganglia …
[HTML][HTML] Comparison of dyskinesia profiles after L-DOPA dose challenges with or without dopamine agonist coadministration
S Grigoriou, E Espa, P Odin, J Timpka… - …, 2023 - Elsevier
Many patients with Parkinson's disease (PD) experiencing l-DOPA-induced dyskinesia (LID)
receive adjunct treatment with dopamine agonists, whose functional impact on LID is …
receive adjunct treatment with dopamine agonists, whose functional impact on LID is …
Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats
P Wang, Y Bi, M Li, J Chen, Z Wang… - Neural Regeneration …, 2025 - journals.lww.com
Long-term levodopa administration can lead to the development of levodopa-induced
dyskinesia. Gamma oscillations are a widely recognized hallmark of abnormal neural …
dyskinesia. Gamma oscillations are a widely recognized hallmark of abnormal neural …
[HTML][HTML] Neurophysiological treatment effects of mesdopetam, pimavanserin and clozapine in a rodent model of Parkinson's disease psychosis
Psychosis in Parkinson's disease is a common phenomenon associated with poor
outcomes. To clarify the pathophysiology of this condition and the mechanisms of …
outcomes. To clarify the pathophysiology of this condition and the mechanisms of …
A comparative study of effects of DOM and lisuride on neuronal activity in nucleus accumbens of freely moving rats
Y Wang, K Jiang, Y Yao, X Liu, R Su - European Journal of Pharmacology, 2025 - Elsevier
dimethoxy-4-methylamphetamine (DOM) and lisuride are both 5-HT 2A receptor partial
agonists. Lisuride exhibits a similar affinity to DOM but lacks hallucinogenic properties …
agonists. Lisuride exhibits a similar affinity to DOM but lacks hallucinogenic properties …
Fenobam modulates distinct electrophysiological mechanisms for regulating excessive gamma oscillations in the striatum of dyskinetic rats
P Wang, W Dai, H Liu, H Liu, Y Xu - Experimental Neurology, 2024 - Elsevier
Gamma oscillations have been frequently observed in levodopa-induced dyskinesia (LID),
manifest as broadband (60-120 Hz) and narrowband (80-110 Hz) gamma activity in cortico …
manifest as broadband (60-120 Hz) and narrowband (80-110 Hz) gamma activity in cortico …
Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson's Disease using diffusion imaging and …
M Moshchin, RJ Schultz, KP Cheng, S Osting, J Koeper… - bioRxiv, 2024 - biorxiv.org
I. Abstract Parkinson's disease (PD) is a multifactorial, progressive neurodegenerative
disease that has a profound impact on those it afflicts. Its hallmark pathophysiology is …
disease that has a profound impact on those it afflicts. Its hallmark pathophysiology is …
L-DOPA induces spatially discrete changes in gene expression in the forebrain of mice with a progressive loss of dopaminergic neurons
A Radlicka-Borysewska, M Ziemiańska, M Zięba… - bioRxiv, 2025 - biorxiv.org
L-3, 4-Dihydroxyphenylalanine (L-DOPA) is effective at alleviating motor impairments in
Parkinson's disease (PD) patients but has mixed effects on nonmotor symptoms and causes …
Parkinson's disease (PD) patients but has mixed effects on nonmotor symptoms and causes …
Temporal features of gamma activity in STN mediated by dopamine receptors in dyskinetic rat
P Wang, W Dai, Y Xu - 2024 - researchsquare.com
Background Levodopa-induced dyskinesia (LID) is a challenging complication in the
advanced stages of Parkinson's disease (PD). Excessive beta and gamma oscillations of PD …
advanced stages of Parkinson's disease (PD). Excessive beta and gamma oscillations of PD …
[HTML][HTML] Local field potentials and neural activity in motor networks in levodopa-induced dykinesia in a model of Parkinson's disease
ES Brazhnik, IE Mysin, NI Novikov - Zhurnal Vysshei Nervnoi Deyatelnosti …, 2024 - snv63.ru
Levodopa, a metabolic precursor of dopamine (DA), is used to treat movement disorders in
Parkinson's disease (PD). Long-term use of levodopa causes a serious side effect known as …
Parkinson's disease (PD). Long-term use of levodopa causes a serious side effect known as …