The epidemiology of Alzheimer's disease modifiable risk factors and prevention
XX Zhang, Y Tian, ZT Wang, YH Ma, L Tan… - The journal of prevention …, 2021 - Springer
Mild Alzheimer's disease is the leading cause of dementia, accounting for 50–70% of cases.
Alzheimer's disease is an irreversible neurodegenerative disease, which affects daily life …
Alzheimer's disease is an irreversible neurodegenerative disease, which affects daily life …
Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases
NJ Jensen, HZ Wodschow, M Nilsson… - International journal of …, 2020 - mdpi.com
Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
[HTML][HTML] The brain as an insulin-sensitive metabolic organ
JL Milstein, HA Ferris - Molecular Metabolism, 2021 - Elsevier
Background The brain was once thought of as an insulin-insensitive organ. We now know
that the insulin receptor is present throughout the brain and serves important functions in …
that the insulin receptor is present throughout the brain and serves important functions in …
[HTML][HTML] Cognitive impairment and type 2 diabetes mellitus: Focus of SGLT2 inhibitors treatment
Gliflozins are a novel class of oral anti-diabetic drugs, acting as inhibitors of sodium-glucose
co-transporters (SGLTs) through the proximal convoluted tubules (PCT) and intestinal …
co-transporters (SGLTs) through the proximal convoluted tubules (PCT) and intestinal …
Metformin use is associated with slowed cognitive decline and reduced incident dementia in older adults with type 2 diabetes: the Sydney memory and ageing study
OBJECTIVE Type 2 diabetes (diabetes) is characterized by accelerated cognitive decline
and higher dementia risk. Controversy exists regarding the impact of metformin, which is …
and higher dementia risk. Controversy exists regarding the impact of metformin, which is …
Treatment with glucagon‐like peptide‐1 receptor agonists and incidence of dementia: data from pooled double‐blind randomized controlled trials and nationwide …
CH Nørgaard, S Friedrich, CT Hansen… - … Research & Clinical …, 2022 - Wiley Online Library
Introduction People with type 2 diabetes have increased risk of dementia. Glucagon‐like
peptide‐1 (GLP‐1) receptor agonists (RAs) are among the promising therapies for …
peptide‐1 (GLP‐1) receptor agonists (RAs) are among the promising therapies for …
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia
Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may
alter dementia onset. Mixed results are emerging from prior observational studies. To …
alter dementia onset. Mixed results are emerging from prior observational studies. To …
Diagnostic, prognostic, and mechanistic biomarkers of diabetes mellitus-associated cognitive decline
Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD),
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …
Sodium-glucose cotransporter 2 (SGLT2) inhibitors vs. dipeptidyl peptidase-4 (DPP4) inhibitors for new-onset dementia: a propensity score-matched population …
Introduction: The effects of sodium-glucose cotransporter 2 inhibitors (SGLT2I) and
dipeptidyl peptidase-4 inhibitors (DPP4I) on new-onset cognitive dysfunction in type 2 …
dipeptidyl peptidase-4 inhibitors (DPP4I) on new-onset cognitive dysfunction in type 2 …
Modulation of brain hyperexcitability: potential new therapeutic approaches in Alzheimer's disease
People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …