Modulation of DNA and RNA by PNA
P Muangkaew, T Vilaivan - Bioorganic & Medicinal Chemistry Letters, 2020 - Elsevier
Peptide nucleic acid (PNA), a synthetic DNA mimic that is devoid of the (deoxy) ribose-
phosphate backbone yet still perfectly retains the ability to recognize natural nucleic acids in …
phosphate backbone yet still perfectly retains the ability to recognize natural nucleic acids in …
Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles
Selective inhibition of microRNAs (miRNAs) offers a new avenue for cancer therapeutics.
While most of the current anti-miRNA (antimiR) reagents target full length miRNAs, here we …
While most of the current anti-miRNA (antimiR) reagents target full length miRNAs, here we …
Peptide nucleic acids: Recent advancements and future opportunities in biomedical applications
Peptide nucleic acids (PNA), synthetic molecules comprising a peptide-like backbone and
natural and unnatural nucleobases, have garnered significant attention for their potential …
natural and unnatural nucleobases, have garnered significant attention for their potential …
Therapeutic potential of chemically modified, synthetic, triplex peptide nucleic acid–based oncomir inhibitors for cancer therapy
Abstract miRNA-155 (miR-155) is overexpressed in various types of lymphomas and
leukemias, suggesting that targeting miR-155 could be a potential platform for the …
leukemias, suggesting that targeting miR-155 could be a potential platform for the …
Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
Targeting oncogenes at the genomic DNA level can open new avenues for precision
medicine. Significant efforts are ongoing to target oncogenes using RNA-targeted and …
medicine. Significant efforts are ongoing to target oncogenes using RNA-targeted and …
A universal discoidal nanoplatform for the intracellular delivery of PNAs
Peptide nucleic acids (PNAs) have gained considerable attention due to their remarkable
potential in gene editing and targeting-based strategies. However, cellular delivery of PNAs …
potential in gene editing and targeting-based strategies. However, cellular delivery of PNAs …
Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for enhanced delivery of antimiR phosphorothioates in cancer cells in vitro
S Malik, R Bahal - Journal of nanobiotechnology, 2019 - Springer
Numerous first generation phosphorothioates (PS) and their derivatives have shown
promise targeting mRNA for therapeutic applications and also gained market approval for …
promise targeting mRNA for therapeutic applications and also gained market approval for …
[HTML][HTML] Formulation of PLGA nanoparticles containing short cationic peptide nucleic acids
Peptide nucleic acids (PNAs) have emerged as one of the most versatile tools with a wide
range of biomedical applications including antisense, antimiR, antigene, as well as site …
range of biomedical applications including antisense, antimiR, antigene, as well as site …
[CITAZIONE][C] Avances da bioloxía molecular e celular na aplicación biomédica: edición xenómica, terapia xénica e inmunoterapia
M Loureiro Veira