A prominent account of prefrontal cortex (PFC) function is that single neurons within the PFC
maintain representations of task-relevant stimuli in working memory. Evidence for this view …

Successful goal-directed behavior requires not only correct action selection, planning, and
execution but also the ability to flexibly adapt behavior when performance problems occur or …

Orbitofrontal cortex (OFC) has long been known to play an important role in decision
making. However, the exact nature of that role has remained elusive. Here, we propose a …

When making a subjective choice, the brain must compute a value for each option and
compare those values to make a decision. The orbitofrontal cortex (OFC) is critically involved …

Reward-guided decision-making and learning depends on distributed neural circuits with
many components. Here we focus on recent evidence that suggests four frontal lobe regions …

In this chapter, we review evidence that the cortical pathways to the hippocampus appear to
extend from two large-scale cortical systems: a posterior medial (PM) system that includes …

Recent work has emphasized the role that orbitofrontal cortex (OFC) has in value-based
decision-making. However, it is also clear that a number of discrepancies have arisen when …

Orbitofrontal cortex (OFC) is widely held to be critical for flexibility in decision-making when
established choice values change. OFC's role in such decision making was investigated in …

The orbitofrontal cortex (OFC) has long been implicated in associative learning. Early work
by Mishkin and Rolls showed that the OFC was critical for rapid changes in learned …

Considerable neuroimaging research in humans indicates that the frontal pole cortex (FPC),
also known as Brodmann area 10, contributes to many aspects of cognition. Despite these …