The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis
elegans, and its biological functions show a high level of evolutionary conservation from the …

MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function
as negative gene regulators. They regulate diverse biological processes, and bioinformatic …

To identify endogenous miRNA-target sites, we isolated AGO-bound RNAs from
Caenorhabditis elegans by individual-nucleotide resolution crosslinking …

It has been difficult to establish whether we are limited to the heart muscle cells we are born
with or if cardiomyocytes are generated also later in life. We have taken advantage of the …

microRNAs (miRNAs) are small noncoding RNAs that play important roles in
posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by …

MicroRNAs (miRNAs) are regulatory RNAs found in multicellular eukaryotes, including
humans, where they are implicated in cancer. The let-7 miRNA times seam cell terminal …

For 50 years the term 'gene'has been synonymous with regions of the genome encoding
mRNAs that are translated into protein. However, recent genome‐wide studies have shown …

The first two known microRNAs (miRNAs), lin-4 and let-7, were originally discovered in the
nematode Caenorhabditis elegans and control the timing of stem-cell division and …

MicroRNAs (miRNAs) are an important class of small noncoding RNAs capable of regulating
other genes' expression. Much progress has been made in computational target prediction …

MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization
of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in …