Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Cancer cells face various metabolic challenges during tumor progression, including growth
in the nutrient-altered and oxygen-deficient microenvironment of the primary site …

Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …

Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute
myeloid leukemia (AML). Early resistance is mediated by the bone marrow …

The epigenetic regulator, MLL4 (KMT2D), has been described as an essential gene in both
humans and mice. In addition, it is one of the most commonly mutated genes in all of cancer …

Folate-mediated one carbon (1C) metabolism supports a series of processes that are
essential for the cell. Through a number of interlinked reactions happening in the cytosol …

Abstract Stearoyl-CoA desaturase 1 (SCD1) converts saturated fatty acids to
monounsaturated fatty acids. The expression of SCD1 is increased in many cancers, and the …

Cancer cells in acidic tumor regions are aggressive and a key therapeutic target, but
distinguishing between acid-exposed and hypoxic cells is challenging. Here, we use …

Malignant brain tumors and metastases pose significant health problems and cause
substantial morbidity and mortality in children and adults. Based on epidemiological …

The central nervous system (CNS) is the most important site of extramedullary disease in
adults with acute lymphoblastic leukemia (ALL). Although CNS disease is identified only in a …