Methods of generating nucleic acid fragments

CRISPR-Cas systems and methods for altering expression of gene products

F Zhang - US Patent 8,697,359, 2014 - Google Patents
The invention provides for systems, methods, and compositions for altering expression of
target gene sequences and related gene products. Provided are vectors and vector systems …
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Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

JA Doudna, M **ek, E Charpentier… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains

F Zhang, L Cong, RJ Platt, NE Sanjana… - US Patent …, 2015 - Google Patents
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CRISPR-Cas component systems, methods and compositions for sequence manipulation

L Cong, F Zhang - US Patent 8,871,445, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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CRISPR-Cas component systems, methods and compositions for sequence manipulation

F Zhang - US Patent 8,795,965, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes

L Cong, F Zhang - US Patent 8,932,814, 2015 - Google Patents
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Engineering of systems, methods and optimized guide compositions for sequence manipulation

F Zhang, L Cong, P Hsu, RAN Fei - US Patent 8,906,616, 2014 - Google Patents
The invention provides for systems, methods, and compositions for manipulation of
sequences and/or activities of target sequences. Provided are vectors and vector systems …
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Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains

F Zhang, L Cong, RJ Platt, NE Sanjana - US Patent 8,999,641, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49883295&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
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Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation

F Zhang, RAN Fei - US Patent 8,865,406, 2014 - Google Patents
The invention provides for engineering and optimization of systems, methods, and
compositions for manipulation of sequences and/or activities of target sequences. Provided …
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CRISPR-Cas systems and methods to alter the expression of gene products

F Zhang - 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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