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Decoding the therapeutic target SVEP1: harnessing molecular trait GWASs to unravel mechanisms of human disease
JS Elenbaas, PC Lee, V Patel… - Annual Review of …, 2025 - annualreviews.org
Although human genetics has substantial potential to illuminate novel disease pathways
and facilitate drug development, identifying causal variants and deciphering their …
and facilitate drug development, identifying causal variants and deciphering their …
[HTML][HTML] microRNAs as promising biomarkers of platelet activity in antiplatelet therapy monitoring
TL Krammer, M Mayr, M Hackl - International Journal of Molecular …, 2020 - mdpi.com
Given the high morbidity and mortality of cardiovascular diseases (CVDs), novel biomarkers
for platelet reactivity are urgently needed. Ischemic events in CVDs are causally linked to …
for platelet reactivity are urgently needed. Ischemic events in CVDs are causally linked to …
Ticagrelor plus aspirin versus clopidogrel plus aspirin for platelet reactivity in patients with minor stroke or transient ischaemic attack: open label, blinded endpoint …
Objective To test the hypothesis that ticagrelor plus aspirin is safe and superior to
clopidogrel plus aspirin for reducing high platelet reactivity at 90 days and stroke recurrence …
clopidogrel plus aspirin for reducing high platelet reactivity at 90 days and stroke recurrence …
[HTML][HTML] Genetic association study and machine learning to investigate differences in platelet reactivity in patients with acute ischemic stroke treated with aspirin
A Ikonnikova, A Anisimova, S Galkin, A Gunchenko… - Biomedicines, 2022 - mdpi.com
Aspirin resistance (AR) is a pressing problem in current ischemic stroke care. Although the
role of genetic variations is widely considered, the data still remain controversial. Our aim …
role of genetic variations is widely considered, the data still remain controversial. Our aim …
[HTML][HTML] The phenomenon of clopidogrel high on-treatment platelet reactivity in ischemic stroke subjects: a comprehensive review
A Wiśniewski, K Filipska - International journal of molecular sciences, 2020 - mdpi.com
Clopidogrel is increasingly being used for the secondary prevention of ischemic stroke
according to the updated guidelines on acute stroke management. Failure to achieve a drug …
according to the updated guidelines on acute stroke management. Failure to achieve a drug …
Platelet function assays for the diagnosis of aspirin resistance
Aspirin, an antiplatelet drug, is commonly used at low doses for numerous indications,
including prophylaxis of cardiovascular, neurovascular, and venous thromboembolic events …
including prophylaxis of cardiovascular, neurovascular, and venous thromboembolic events …
Monitoring antiplatelet therapy: where are we now?
Single antiplatelet therapy represents the cornerstone of thrombosis prevention in
atherosclerotic cardiovascular disease. Dual antiplatelet therapy (DAPT), consisting of …
atherosclerotic cardiovascular disease. Dual antiplatelet therapy (DAPT), consisting of …
Safety and efficacy of dual antiplatelet pretreatment in patients with ischemic stroke treated with IV thrombolysis: a systematic review and meta-analysis
Objective Conflicting data exist on the safety and efficacy of IV thrombolysis (IVT) in patients
with acute ischemic stroke (AIS) receiving dual antiplatelet pretreatment (DAPP). The aim of …
with acute ischemic stroke (AIS) receiving dual antiplatelet pretreatment (DAPP). The aim of …
High on-clopidogrel platelet reactivity in ischaemic stroke or transient ischaemic attack: systematic review and meta-analysis
Objectives To assess the prevalence of high on-clopidogrel platelet reactivity (HCPR) in
patients with ischaemic stroke or transient ischaemic attack (IS/TIA), their outcome and …
patients with ischaemic stroke or transient ischaemic attack (IS/TIA), their outcome and …
Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis
Background The prevalence of ex vivo 'high on-treatment platelet reactivity (HTPR)'and its
relationship with recurrent vascular events/outcomes in patients with ischaemic …
relationship with recurrent vascular events/outcomes in patients with ischaemic …