New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data
Biological systems are immensely complex, organized into a multi-scale hierarchy of
functional units based on tightly regulated interactions between distinct molecules, cells …
functional units based on tightly regulated interactions between distinct molecules, cells …
The impact of sex on gene expression across human tissues
INTRODUCTION Many complex human phenotypes, including diseases, exhibit sex-
differentiated characteristics. These sex differences have been variously attributed to …
differentiated characteristics. These sex differences have been variously attributed to …
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease
Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques
Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex
and hippocampus of male and female App NL-GF mice over time demonstrate that …
and hippocampus of male and female App NL-GF mice over time demonstrate that …
An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease
Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients
Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …
[HTML][HTML] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
[HTML][HTML] Multiscale analysis of independent Alzheimer's cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus
Investigators have long suspected that pathogenic microbes might contribute to the onset
and progression of Alzheimer's disease (AD) although definitive evidence has not been …
and progression of Alzheimer's disease (AD) although definitive evidence has not been …