Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Microorganisms produce small bioactive compounds as part of their secondary or
specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal …

With an ever-increasing amount of (meta) genomic data being deposited in sequence
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …

Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

Cells of most bacterial species are around 2 micrometers in length, with some of the largest
specimens reaching 750 micrometers. Using fluorescence, x-ray, and electron microscopy in …

Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …

Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

The increasing frequency of extreme weather events highlights the need to understand how
soil microbiomes respond to such disturbances. Here, metagenomics was used to …

Soil-dwelling microbes are the principal inoculum for the root microbiota, but our
understanding of microbe–microbe interactions in microbiota establishment remains …