The improper distribution of chromosomes during mitosis compromises cellular functions
and can reduce cellular fitness or contribute to malignant transformation. As a …

Cancer has always been a worldwide problem, and the application of radiotherapy has
greatly improved the survival rate of cancer patients. Radiotherapy can modulate multiple …

Mistakes during cell division frequently generate changes in chromosome content,
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …

Background & Aims Chromosomal instability (CIN) is a carcinogenesis event that promotes
metastasis and resistance to therapy by unclear mechanisms. Expression of the colon …

Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell
division. Multipolar spindles are often seen in human cancers and are usually associated …

Historically, cancers have been treated with chemotherapeutics aimed to have profound
effects on tumor cells with only limited effects on normal tissue. This approach was followed …

The unique ability of centrosomes to nucleate and organize microtubules makes them
unrivaled conductors of important interphase processes, such as intracellular payload traffic …

OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic
Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific …

Polo-like kinase 4 (PLK4) is a serine/threonine kinase regulating centriole duplication. CFI-
400945 is a highly selective PLK4 inhibitor that deregulates centriole duplication, causing …

Nearly a century ago, cell biologists postulated that the chromosomal aberrations blighting
cancer cells might be caused by a mysterious organelle—the centrosome—that had only …