Enantioselective radical reactions using chiral catalysts
Benefiting from the impressive increase in fundamental knowledge, the last 20 years have
shown a continuous burst of new ideas and consequently a plethora of new catalytic …
shown a continuous burst of new ideas and consequently a plethora of new catalytic …
Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses
Enzyme cascades are a powerful technology to develop environmentally friendly and cost-
effective synthetic processes to manufacture drugs, as they couple different …
effective synthetic processes to manufacture drugs, as they couple different …
Recent trends in biocatalysis
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods
S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …
Biocatalysis making waves in organic chemistry
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …
biocatalysis has developed, and in doing so changed our perception of what organic …
Direct visible-light-excited flavoproteins for redox-neutral asymmetric radical hydroarylation
B Zhao, J Feng, L Yu, Z **ng, B Chen, A Liu, F Liu… - Nature Catalysis, 2023 - nature.com
State-of-the-art non-natural photoenzymatic catalysis typically relies on either ultraviolet light
activation or the formation of electron donor–acceptor complexes. Inspired by nature, herein …
activation or the formation of electron donor–acceptor complexes. Inspired by nature, herein …
Combining chemistry and protein engineering for new-to-nature biocatalysis
Biocatalysis, the application of enzymes to solve synthetic problems of human import, has
blossomed into a powerful technology for chemical innovation. In the past decade, a …
blossomed into a powerful technology for chemical innovation. In the past decade, a …
Biocatalysis as key to sustainable industrial chemistry
The role and power of biocatalysis in sustainable chemistry has been continuously brought
forward step by step to its present outstanding position. The problem‐solving capabilities of …
forward step by step to its present outstanding position. The problem‐solving capabilities of …
Expanding the synthetic toolbox through metal–enzyme cascade reactions
S González-Granda, J Albarrán-Velo… - Chemical …, 2023 - ACS Publications
The combination of metal-, photo-, enzyme-, and/or organocatalysis provides multiple
synthetic solutions, especially when the creation of chiral centers is involved. Historically …
synthetic solutions, especially when the creation of chiral centers is involved. Historically …
Expanding chemistry through in vitro and in vivo biocatalysis
Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …