Enantioselective radical reactions using chiral catalysts

S Mondal, F Dumur, D Gigmes, MP Sibi… - Chemical …, 2022 - ACS Publications
Benefiting from the impressive increase in fundamental knowledge, the last 20 years have
shown a continuous burst of new ideas and consequently a plethora of new catalytic …

Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses

AI Benítez-Mateos, D Roura Padrosa, F Paradisi - Nature chemistry, 2022 - nature.com
Enzyme cascades are a powerful technology to develop environmentally friendly and cost-
effective synthetic processes to manufacture drugs, as they couple different …

Recent trends in biocatalysis

D Yi, T Bayer, CPS Badenhorst, S Wu… - Chemical Society …, 2021 - pubs.rsc.org
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Biocatalysis making waves in organic chemistry

U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Direct visible-light-excited flavoproteins for redox-neutral asymmetric radical hydroarylation

B Zhao, J Feng, L Yu, Z **ng, B Chen, A Liu, F Liu… - Nature Catalysis, 2023 - nature.com
State-of-the-art non-natural photoenzymatic catalysis typically relies on either ultraviolet light
activation or the formation of electron donor–acceptor complexes. Inspired by nature, herein …

Combining chemistry and protein engineering for new-to-nature biocatalysis

DC Miller, SV Athavale, FH Arnold - Nature Synthesis, 2022 - nature.com
Biocatalysis, the application of enzymes to solve synthetic problems of human import, has
blossomed into a powerful technology for chemical innovation. In the past decade, a …

Biocatalysis as key to sustainable industrial chemistry

AR Alcántara, P Domínguez de María… - …, 2022 - Wiley Online Library
The role and power of biocatalysis in sustainable chemistry has been continuously brought
forward step by step to its present outstanding position. The problem‐solving capabilities of …

Expanding the synthetic toolbox through metal–enzyme cascade reactions

S González-Granda, J Albarrán-Velo… - Chemical …, 2023 - ACS Publications
The combination of metal-, photo-, enzyme-, and/or organocatalysis provides multiple
synthetic solutions, especially when the creation of chiral centers is involved. Historically …

Expanding chemistry through in vitro and in vivo biocatalysis

EN Kissman, MB Sosa, DC Millar, EJ Koleski… - Nature, 2024 - nature.com
Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …