Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to …
Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …
Glucose control in the ICU: a continuing story
In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic
closed-loop systems, measures of accuracy and of quality of glucose control need to be …
closed-loop systems, measures of accuracy and of quality of glucose control need to be …
Generalisability of a virtual trials method for glycaemic control in intensive care
Background: Elevated blood glucose (BG) concentrations (Hyperglycaemia) are a common
complication in critically ill patients. Insulin therapy is commonly used to treat …
complication in critically ill patients. Insulin therapy is commonly used to treat …
Untangling glycaemia and mortality in critical care
Background Hyperglycaemia is associated with adverse outcomes in the intensive care unit,
and initial studies suggested outcome benefits of glycaemic control (GC). However …
and initial studies suggested outcome benefits of glycaemic control (GC). However …
[HTML][HTML] Percentage of time in range 70 to 139 mg/dL is associated with reduced mortality among critically ill patients receiving IV insulin infusion
Background In addition to hyperglycemia, hypoglycemia, and glycemic variability, reduced
time in targeted blood glucose range (TIR) is associated with increased risk of death in …
time in targeted blood glucose range (TIR) is associated with increased risk of death in …
Glycemic control in the intensive care unit: a control systems perspective
Computers and automation have revolutionised quality and productivity in many industries,
but not in medicine. Healthcare costs are thus growing beyond the ability of society to pay for …
but not in medicine. Healthcare costs are thus growing beyond the ability of society to pay for …
Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas
There is considerable physiological and clinical evidence of harm and increased risk of
death associated with dysglycemia in critical care. However, glycemic control (GC) currently …
death associated with dysglycemia in critical care. However, glycemic control (GC) currently …
Clinical effectiveness of intravenous exenatide infusion in perioperative glycemic control after coronary artery bypass graft surgery
Background: We aimed to assess the clinical effectiveness of intravenous exenatide
compared to insulin in perioperative blood glucose control in coronary artery bypass grafting …
compared to insulin in perioperative blood glucose control in coronary artery bypass grafting …
A 3D insulin sensitivity prediction model enables more patient-specific prediction and model-based glycaemic control
Background Insulin therapy for glycaemic control (GC) in critically ill patients may improve
outcomes by reducing hyperglycaemia and glycaemic variability, which are both associated …
outcomes by reducing hyperglycaemia and glycaemic variability, which are both associated …
3D kernel-density stochastic model for more personalized glycaemic control: development and in-silico validation
Background The challenges of glycaemic control in critically ill patients have been debated
for 20 years. While glycaemic control shows benefits inter-and intra-patient metabolic …
for 20 years. While glycaemic control shows benefits inter-and intra-patient metabolic …