Thermoacidophilic archaea belonging to the order Sulfolobales thrive in extreme biotopes,
such as sulfuric hot springs and ore deposits. These microorganisms have been model …

The known diversity of metabolic strategies and physiological adaptations of archaeal
species to extreme environments is extraordinary. Accurate and responsive mechanisms to …

CRISPR–Cas system provides the adaptive immunity against invading genetic elements in
prokaryotes. Recently, we demonstrated that Csa3a regulator mediates spacer acquisition in …

CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archaea
from invading nucleic acids. Type III systems (Cmr, Csm) have been shown to cleave RNA …

Transcription is enabled by RNA polymerase and general factors that allow its progress
through the transcription cycle by facilitating initiation, elongation and termination. The …

To elucidate the mechanism of transcription by cellular RNA polymerases (RNAPs), high-
resolution X-ray crystal structures together with structure-guided biochemical, biophysical …

The archaeal RNA polymerase (RNAP) is a double-psi β-barrel enzyme closely related to
eukaryotic RNAPII in terms of subunit composition and architecture, promoter elements and …

RNA polymerases (RNAPs) make repeatedly use of their templates by cycling through
initiation, elongation and termination phases of transcription; during each step RNAP is …

While bacteria and eukaryotes show distinct mechanisms of DNA damage response (DDR)
regulation, investigation of ultraviolet (UV)-responsive expression in a few archaea did not …

During transcription initiation, the promoter DNA is recognized and bent by the basal
transcription factor TATA-binding protein (TBP). Subsequent association of transcription …