Genetic alterations and their clinical implications in DLBCL

Y Miao, LJ Medeiros, Y Li, J Li, KH Young - Nature reviews Clinical …, 2019 - nature.com
Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm with
variations in gene expression profiles and genetic alterations, which lead to substantial …

Prognostication of diffuse large B-cell lymphoma in the molecular era: moving beyond the IPI

JC Wight, G Chong, AP Grigg, EA Hawkes - Blood reviews, 2018 - Elsevier
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with variable outcomes.
Despite the majority of patients being cured with combination chemoimmunotherapy, up to …

Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma …

K Dunleavy, MA Fanale, JS Abramson, A Noy… - The Lancet …, 2018 - thelancet.com
Background MYC gene rearrangement is present in approximately 10% of aggressive B-cell
lymphomas, with half also harbouring a BCL2 gene rearrangement. Multiple retrospective …

Outcomes in patients with aggressive B‐cell non‐Hodgkin lymphoma after intensive frontline treatment failure

EC Ayers, S Li, LJ Medeiros, DA Bond, KJ Maddocks… - Cancer, 2020 - Wiley Online Library
Background Salvage immunochemotherapy followed by high‐dose chemotherapy and
autologous stem cell transplantation is the standard‐of‐care second‐line treatment for …

Molecular classification and therapeutics in diffuse large B-cell lymphoma

G Shimkus, T Nonaka - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Diffuse large B-cell lymphoma (DLBCL) encompasses a wide variety of disease states that
have to date been subgrouped and characterized based on immunohistochemical methods …

CUL4B regulates autophagy via JNK signaling in diffuse large B-cell lymphoma

Y Li, X Zhou, Y Zhang, J Yang, Y Xu, Y Zhao, X Wang - Cell Cycle, 2019 - Taylor & Francis
Aberrant expression of CUL4B was identified in various types of solid cancers. Cumulative
evidences support the oncogenic role of CUL4B in cancers, including regulation of cell …

Diffuse large B-cell lymphoma in the public-sector of Johannesburg, South Africa, in the era of widescale antiretroviral therapy use

J Vaughan, Y Perner, T Wiggill - JAIDS Journal of Acquired …, 2022 - journals.lww.com
Background: Diffuse large B-cell lymphoma (DLBCL) is a high-grade non-Hodgkin
lymphoma with increased incidence among people living with HIV-infection (PLWH) …

Burkitt lymphoma and other high-grade B-cell lymphomas with or without MYC, BCL2, and/or BCL6 rearrangements

R Alsharif, K Dunleavy - Hematology/Oncology Clinics, 2019 - hemonc.theclinics.com
Since the publication of the fourth edition of the World Health Organization (WHO)
Classification of Hematopoietic and Lymphoid Tumors in 2008, the authors have made …

Upfront therapy for diffuse large B-cell lymphoma: looking beyond R-CHOP

BT Hill, B Kahl - Expert Review of Hematology, 2022 - Taylor & Francis
Introduction Diffuse large B-cell lymphoma (DLBCL) is not a single entity but instead
represents a collection of interrelated malignancies having distinct molecular features …

Molekulare Klassifizierung und Therapien des diffusen großzelligen B-Zell-Lymphoms

G Shimkus, T Nonaka - Kompass Onkologie, 2023 - karger.com
Das diffuse großzellige B-Zell-Lymphom (DLBCL) umfasst eine Vielzahl von
Krankheitsbildern, die bisher auf der Basis immunhistochemischer Methoden in …