Mitochondrial structure often determines the function of these highly dynamic,
multifunctional, eukaryotic organelles, which are essential for maintaining cellular health …

Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

All-solid-state batteries suffer from a loss of contact between the electrode and electrolyte
particles, leading to poor cyclability. Here, a void-free ion-permeable interface between the …

Hematopoietic stem cells (HSCs) have a number of unique physiologic adaptations that
enable lifelong maintenance of blood cell production, including a highly regulated rate of …

ABCA7 loss-of-function variants are associated with increased risk of Alzheimer's disease
(AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we …

During aging, muscle gradually undergoes sarcopenia, the loss of function associated with
loss of mass, strength, endurance, and oxidative capacity. However, the 3D structural …

This review provides an overview of the current methods for quantifying mitochondrial
ultrastructure, including cristae morphology, mitochondrial contact sites, and recycling …

As a common pathology of many ocular disorders such as diabetic retinopathy and
glaucoma, retinal ischemia/reperfusion (IR) triggers inflammation and microglia activation …

Abstract Background Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic
reticulum (ER)-mitochondria signaling plays a key role in the neuronal cytopathology of …

Background and aims Obesity is a state of chronic low-grade systemic inflammation. Recent
studies showed that NLRP3 inflammasome initiates metabolic dysregulation in adipose …