The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …

Virtual patients and digital patients/twins are two similar concepts gaining increasing
attention in health care with goals to accelerate drug development and improve patients' …

Brain metastases signify a deleterious milestone in the progression of several advanced
cancers, predominantly originating from lung, breast and melanoma malignancies, with a …

Triple-negative breast cancer (TNBC) is generally regarded as the most aggressive subtype
among breast cancers, but exhibits higher chemotherapeutic and immunotherapeutic …

Low response rate, treatment relapse, and resistance remain key challenges for cancer
treatment with immune checkpoint blockade (ICB). Here we report that loss of specific tumor …

The study of the metastatic cascade has revealed the complexity of the process and the
multiple cellular states that disseminated cancer cells must go through. The tumor …

Brain metastases (BrMs) evade the immune response to develop in the brain, yet the
mechanisms of BrM immune evasion remains unclear. This study shows that brain …

Despite the success of immune checkpoint inhibition (ICI) in treating cancer, patients with
triple-negative breast cancer (TNBC) often develop resistance to therapy, and the underlying …

Opinion statement Recently, the addition of PD-1 pathway targeting immune checkpoint
inhibitors (ICI) to standard neoadjuvant chemotherapy for early-stage triple-negative breast …

Metastatic cancer represents the main cause of death in patients with cancer. However,
basic and translational research is hampered by the limited availability of metastatic …