BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …

Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …

Abstract Purpose of Review Our 24/7 society is dependent on shift work, despite mounting
evidence for negative health outcomes from sleep displacement due to shift work. This …

At the core of human thought, for the majority of individuals in the developed nations at least,
there is the tacit assumption that as a species we are unfettered by the demands imposed by …

Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by
the molecular circadian clock which acting on coordinating internal time with the external …

Mammals rely on a network of circadian clocks to control daily systemic metabolism and
physiology. The central pacemaker in the suprachiasmatic nucleus (SCN) is considered …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …

Hypertension is extremely common, affecting approximately 1 in every 2 adults globally.
Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and …

The mammalian circadian system, which is comprised of multiple cellular clocks located in
the organs and tissues, orchestrates their regulation in a hierarchical manner throughout the …