The corticostriatal pathway provides most of the excitatory glutamatergic input into the
striatum and it plays an important role in the development of the phenotype of Huntington's …

Hippocampus plays an important role in learning and memory and in spatial navigation.
Production of new neurons that are functionally integrated into the hippocampal neuronal …

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, modulates
neuronal survival, differentiation, and synaptic function. Reduced BDNF expression in the …

Huntington's disease (HD) is a devastating neurodegenerative disorder caused by a CAG
repeat expansion encoding an extended polyglutamine tract in the huntingtin protein …

The mechanism that controls the selective vulnerability of striatal neurons in Huntington's
disease is unclear. Brain-derived neurotrophic factor (BDNF) protects striatal neurons and is …

There is growing evidence that reduced neurotrophic support is a significant factor in the
pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's …

Huntingtin is a protein of 348kDa that is mutated in Huntington's disease (HD), a dominantly
inherited neurodegenerative disorder. Previous data have led us to propose that aspects of …

Peripheral neuropathy afflicts 60% of all diabetic patients. Underlying the clinical disorder is
the loss or degeneration of neurons, Schwann cells, and neuronal fibers. This degenerative …

The purpose of this study was to evaluate the therapeutic effects of the transplantation of
bone-marrow mesenchymal stem cells (MSCs), genetically engineered to over-express …

HT7 receptors (5-HT7R) are the most recently identified among the family of serotonin
receptors. Their role in health and disease, particularly as mediators of, and druggable …