Ramalin inhibits differentiation of 3T3-L1 preadipocytes and suppresses adiposity and body weight in a high-fat diet-fed C57BL/6J mice

SY Kim, YJ Jang, B Park, JH Yim, HK Lee… - Chemico-Biological …, 2016 - Elsevier
Obesity is a serious global health problem. Natural substances that could be effective
remedies for treatment of obesity, and which are relatively safe, are desired. The aim of this …

Method for synthesizing ramalin and ramalin precursor by using glutamic acid derivative and hydroxy aniline or hydroxy aniline having protected hydroxy group

JH Yim, IC Kim, D Kim, SJ Han, HS Lee… - US Patent …, 2016 - Google Patents
Disclosed is a method of the synthesis of ramalin. It com prises reacting a glutamic acid
derivative, which is prepared using alkylchloroformate, with a hydrazine Salt compound …

Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin

JH Yim, IC Kim, SG Lee, DK Kim, SJ Han… - US Patent …, 2017 - Google Patents
The present invention relates to the novel use (anti-inflam matory activity) of Ramalin
isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a phar …

Effects of Steric Hindrance of 2-Hydroxyphenyl Diazonium Derivatives in the Reductive Reaction by Using Sodium Hydrogensulfite

O Kwon, J Kim, SM Park, KS Kim… - Applied Chemistry for …, 2019 - koreascience.kr
Hydrazine derivatives used in fine chemicals, pharmaceuticals and cosmetics can be
synthesized by reduction reaction from diazonium derivatives. The reduction method using …

Sodium Hydrogensulfite 를 이용한 환원반응에서 2-Hydroxyphenyl Diazonium 유도체의 입체장애에 관한 연구

권오준, 김지언, 박세민, 김근식, 윤순도 - 공업화학, 2019 - kiss.kstudy.com
정밀화학 및 의약품, 화장품에 사용되는 hydrazine 유도체는 diazonium salt 로부터 환원반응을
통해 합성할 수 있다. SnCl 2 를 이용한 환원방법은 반응 전환이 용이하나 반응 후 최종 제품에 …

Pharmaceutical composition for preventing or treating hepatic fibrosis and cirrhosis containing ramalin

JH Yim, IC Kim, SJ Han, HS Lee, HD Bhattarai… - US Patent …, 2016 - Google Patents
There is provided a novel use of ramalin for preventing or treating liver diseases, and more
specifically, a pharmaceuti cal composition for preventing or treating hepatic fibrosis or …