Biofilm formation and inhibition mediated by bacterial quorum sensing

Y Wang, Z Bian, Y Wang - Applied Microbiology and Biotechnology, 2022 - Springer
As a complex microbial aggregate, biofilm is a group behavior of bacterial ability to adapt to
the environment. Bacteria produce biofilm substrates that enhance their tolerance to stress …

Recent advances in anti-virulence therapeutic strategies with a focus on dismantling bacterial membrane microdomains, toxin neutralization, quorum-sensing …

O Fleitas Martínez, MH Cardoso, SM Ribeiro… - Frontiers in cellular …, 2019 - frontiersin.org
Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

Disruption of communication: recent advances in antibiofilm materials with anti-quorum sensing properties

Y Qu, Y Zou, G Wang, Y Zhang… - ACS Applied Materials & …, 2024 - ACS Publications
Biofilm contamination presents a significant threat to public health, the food industry, and
aquatic/marine-related applications. In recent decades, although various methods have …

Commensal staphylococci influence Staphylococcus aureus skin colonization and disease

CP Parlet, MM Brown, AR Horswill - Trends in microbiology, 2019 - cell.com
Commensal organisms that constitute the skin microbiota play a pivotal role in the
orchestration of cutaneous homeostasis and immune competence. This balance can be …

The staphylococcal biofilm: adhesins, regulation, and host response

AE Paharik, AR Horswill - Virulence mechanisms of bacterial …, 2016 - Wiley Online Library
The Staphylococcus genus includes a diverse group of commensals that colonize mammals
on the skin or mucous membranes. Some of the best‐known members of this genus, such as …

Antibacterial activities of anthraquinones: structure–activity relationships and action mechanisms

T Qun, T Zhou, J Hao, C Wang, K Zhang, J Xu… - RSC Medicinal …, 2023 - pubs.rsc.org
With the increasing prevalence of untreatable infections caused by antibiotic-resistant
bacteria, the discovery of new drugs from natural products has become a hot research topic …

Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy

C Kong, H Neoh, S Nathan - Toxins, 2016 - mdpi.com
Staphylococcus aureus is an opportunistic pathogen and the leading cause of a wide range
of severe clinical infections. The range of diseases reflects the diversity of virulence factors …

Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) System

L Tan, SR Li, B Jiang, XM Hu, S Li - Frontiers in microbiology, 2018 - frontiersin.org
Staphylococcus aureus can cause numerous different diseases, which has been attributed
to its large repertoire of virulence factors, many of which are under the control of the …

Coagulase-negative staphylococcal strain prevents Staphylococcus aureus colonization and skin infection by blocking quorum sensing

AE Paharik, CP Parlet, N Chung, DA Todd… - Cell host & …, 2017 - cell.com
Coagulase-negative staphylococci (CoNS) and Staphylococcus aureus are part of the
natural flora of humans and other mammals. We found that spent media from the CoNS …

Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

JM Sadowska, KJ Genoud, DJ Kelly, FJ O'Brien - Materials Today, 2021 - Elsevier
Eliminating bacterial infection and simultaneously providing a bioactive environment for
bone growth during treatment of severe osteomyelitis is one of the greatest global …