To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered
through functional genomics studies. Importantly, lncRNAs have been shown, in many …

A major shift in our understanding of genome regulation has emerged recently. It is now
apparent that the majority of cellular transcripts do not code for proteins, and many of them …

The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of
breast cancer tumors. However, the underlying mechanism is not fully understood. Here …

A significant portion of the human genome encodes genes that transcribe long nonprotein-
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …

Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and
functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a …

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal
role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master …

mRNA stability influences gene expression and translation in almost all living organisms,
and the levels of mRNA molecules in the cell are determined by a balance between …

Background The conversion from estrogen-dependent to estrogen-independent state of ER+
breast cancer cells is the key step to promote resistance to endocrine therapies. Although …

MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA
silencing and post-transcriptional regulation of gene expression. They can mediate a fine …

Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of …