Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative
metabolism in mitochondria is the main energy source of the heart, and the inability to …

Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …

Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Rationale: Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical
syndrome without effective therapies. We recently demonstrated in mice that a combination …

Diabetes is a chronic metabolic disease that is increasing in prevalence and causes many
complications. Diabetic cardiomyopathy (DCM) is a complication of diabetes that is …