Background and aims Advances in genomic technologies have led to increasing reports of
monogenic inflammatory bowel disease (IBD). However, there has not been a detailed …

The advent of next-generation sequencing (NGS) in 2010 has transformed medicine,
particularly the growing field of inborn errors of immunity. NGS has facilitated the discovery …

Type I interferons (IFNs) play a central role in the immune defense against viral infections.
Type I IFN activation is induced by pattern-recognition receptors of the innate immune …

Type I interferon is a potent substance. As such, the induction, transmission, and resolution
of the type I interferon–mediated immune response are tightly regulated. As defined, the type …

Background & aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the
essential roles of individual genes in pathways and networks safeguarding immune …

Purpose Increased type I interferon is considered relevant to the pathology of a number of
monogenic and complex disorders spanning pediatric rheumatology, neurology, and …

Notable advances in gene sequencing methods in recent years have permitted enormous
progress in the phenotypic and genotypic characterization of autoinflammatory syndromes …

Genomic technologies inform the complex genetic basis of polygenic inflammatory bowel
disease (IBD) as well as Mendelian disease-associated IBD. Aiming to diagnose patients …

A virus hijacks host cellular machineries and metabolites in order to reproduce. In response,
the innate immune system activates different processes to fight back. Although many aspects …

A number of systemic autoinflammatory diseases arise from gain-of-function mutations in
genes encoding IL-1–activating inflammasomes or cytoplasmic nucleic acid sensors …