Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …

Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Single-cell and spatial technologies that profile gene expression across a whole tissue are
revolutionizing the resolution of molecular states in clinical samples. Current commercially …

The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …

Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Although heterogeneity of FAP+ Cancer-Associated Fibroblasts (CAF) has been described
in breast cancer, their plasticity and spatial distribution remain poorly understood. Here, we …

Understanding tumor microenvironment (TME) reprogramming in gastric adenocarcinoma
(GAC) progression may uncover novel therapeutic targets. Here, we performed single-cell …

Optimal integration of transcriptomics data and associated spatial information is essential
towards fully exploiting spatial transcriptomics to dissect tissue heterogeneity and map out …

Single cell and spatial technologies that profile gene expression across a whole tissue are
revolutionizing the resolution of molecular states in clinical tissue samples. Commercially …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …