Signaling pathways involved in the regulation of mRNA translation
Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
Abstract N 6-methyladenosine (m 6 A) is the most abundant internal modification in
eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and …
eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and …
METTL14 inhibits hematopoietic stem/progenitor differentiation and promotes leukemogenesis via mRNA m6A modification
Summary N 6-methyladenosine (m 6 A), the most prevalent internal modification in
eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However …
eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However …
The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution
Modifications on mRNA offer the potential of regulating mRNA fate post-transcriptionally.
Recent studies suggested the widespread presence of N 1-methyladenosine (m1A), which …
Recent studies suggested the widespread presence of N 1-methyladenosine (m1A), which …
RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia
Summary N 6-methyladenosine (m 6 A), the most abundant internal modification in mRNA,
has been implicated in tumorigenesis. As an m 6 A demethylase, ALKBH5 has been shown …
has been implicated in tumorigenesis. As an m 6 A demethylase, ALKBH5 has been shown …
Transcriptome-wide map** of internal N7-methylguanosine methylome in mammalian mRNA
Summary N 7-methylguanosine (m 7 G) is a positively charged, essential modification at the
5′ cap of eukaryotic mRNA, regulating mRNA export, translation, and splicing. m 7 G also …
5′ cap of eukaryotic mRNA, regulating mRNA export, translation, and splicing. m 7 G also …
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …
small subset of these cells generates metastases. We conducted an in vivo genome-wide …
[HTML][HTML] Regulation of gene expression via translational buffering
Translation of an mRNA represents a critical step during the expression of protein-coding
genes. As mechanisms governing post-transcriptional regulation of gene expression are …
genes. As mechanisms governing post-transcriptional regulation of gene expression are …
Insulin/IGF-1 drives PERIOD synthesis to entrain circadian rhythms with feeding time
In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting
cues, adjusting internal∼ 24 h rhythms to resonate with, and anticipate, external cycles of …
cues, adjusting internal∼ 24 h rhythms to resonate with, and anticipate, external cycles of …
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis
Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase
MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and …
MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and …