Fracture risk is increased in patients with type 2 diabetes mellitus (T2DM). In addition, these
patients sustain fractures despite having higher levels of areal bone mineral density, as …

Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …

Background The association between obesity and fracture risk may be skeletal site-and sex-
specific but results among studies are inconsistent. Whilst several studies reported higher …

Diabetes compromises bone cell metabolism and function, resulting in increased risk of
fragility fracture. Advanced glycation end products (AGEs) interact with the receptor for AGEs …

There is substantial, and growing, evidence that type 2 diabetes (T2D) is associated with
skeletal fragility, despite often preserved bone mineral density. As post-fracture outcomes …

Background Osteoporosis has already been a growing health concern worldwide. The
influence of living area, lifestyle, socioeconomic, and medical conditions on the occurrence …

Abstract Type 2 diabetes (T2D) is associated with numerous complications, including
increased risk of fragility fractures, despite seemingly protective factors [eg, normal bone …

Objective To assess whether eldecalcitol, an active vitamin D analogue 2, can reduce the
development of type 2 diabetes among adults with impaired glucose tolerance. Design …

Obesity is associated with increased risk for fragility fractures. However, the cellular
mechanisms are unknown. Using a translational approach combining RNA sequencing and …

Despite a clear association between type 2 diabetes (T2D) and fracture risk, the
pathogenesis of bone fragility in T2D has not been clearly elucidated. Insulin resistance is …