Nanopore-based technologies beyond DNA sequencing

YL Ying, ZL Hu, S Zhang, Y Qing, A Fragasso… - Nature …, 2022 - nature.com
Inspired by the biological processes of molecular recognition and transportation across
membranes, nanopore techniques have evolved in recent decades as ultrasensitive …

Engineering biological nanopore approaches toward protein sequencing

X Wei, T Penkauskas, JE Reiner, C Kennard… - ACS …, 2023 - ACS Publications
Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

Digital immunoassay for biomarker concentration quantification using solid-state nanopores

L He, DR Tessier, K Briggs, M Tsangaris… - Nature …, 2021 - nature.com
Single-molecule counting is the most accurate and precise method for determining the
concentration of a biomarker in solution and is leading to the emergence of digital diagnostic …

The application of single molecule nanopore sensing for quantitative analysis

Y Wu, JJ Gooding - Chemical Society Reviews, 2022 - pubs.rsc.org
Nanopore-based sensors typically work by monitoring transient pulses in conductance via
current–time traces as molecules translocate through the nanopore. The unique property of …

A reversibly gated protein-transporting membrane channel made of DNA

S Dey, A Dorey, L Abraham, Y **ng, I Zhang… - Nature …, 2022 - nature.com
Controlled transport of biomolecules across lipid bilayer membranes is of profound
significance in biological processes. In cells, cargo exchange is mediated by dedicated …

Solid-state nanopore fabrication by automated controlled breakdown

M Waugh, K Briggs, D Gunn, M Gibeault, S King… - Nature …, 2020 - nature.com
Solid-state nanopores are now well established as single-biomolecule sensors that hold
great promise as sensing elements in diagnostic and sequencing applications. However …

Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges

G Liu, C Jiang, X Lin, Y Yang - View, 2021 - Wiley Online Library
Cytokines are signaling molecules between cells in immune system. Cytokine storm, due to
the sudden acute increase in levels of pro‐inflammatory circulating cytokines, can result in …

Electronic and electrochemical viral detection for point-of-care use: A systematic review

S Monteil, AJ Casson, ST Jones - PLoS One, 2021 - journals.plos.org
Detecting viruses, which have significant impact on health and the economy, is essential for
controlling and combating viral infections. In recent years there has been a focus towards …

Precise DNA concentration measurements with nanopores by controlled counting

M Charron, K Briggs, S King, M Waugh… - Analytical …, 2019 - ACS Publications
Using a solid-state nanopore to measure the concentration of clinically relevant target
analytes, such as proteins or specific DNA sequences, is a major goal of nanopore research …

Flossing DNA in a dual nanopore device

X Liu, P Zimny, Y Zhang, A Rana, R Nagel, W Reisner… - Small, 2020 - Wiley Online Library
Solid‐state nanopores are a single‐molecule technique that can provide access to
biomolecular information that is otherwise masked by ensemble averaging. A promising …