Nanopore-based technologies beyond DNA sequencing
Inspired by the biological processes of molecular recognition and transportation across
membranes, nanopore techniques have evolved in recent decades as ultrasensitive …
membranes, nanopore techniques have evolved in recent decades as ultrasensitive …
Engineering biological nanopore approaches toward protein sequencing
Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …
protein studies, while the methods we have for identifying and quantifying individual proteins …
Digital immunoassay for biomarker concentration quantification using solid-state nanopores
Single-molecule counting is the most accurate and precise method for determining the
concentration of a biomarker in solution and is leading to the emergence of digital diagnostic …
concentration of a biomarker in solution and is leading to the emergence of digital diagnostic …
The application of single molecule nanopore sensing for quantitative analysis
Nanopore-based sensors typically work by monitoring transient pulses in conductance via
current–time traces as molecules translocate through the nanopore. The unique property of …
current–time traces as molecules translocate through the nanopore. The unique property of …
A reversibly gated protein-transporting membrane channel made of DNA
Controlled transport of biomolecules across lipid bilayer membranes is of profound
significance in biological processes. In cells, cargo exchange is mediated by dedicated …
significance in biological processes. In cells, cargo exchange is mediated by dedicated …
Solid-state nanopore fabrication by automated controlled breakdown
M Waugh, K Briggs, D Gunn, M Gibeault, S King… - Nature …, 2020 - nature.com
Solid-state nanopores are now well established as single-biomolecule sensors that hold
great promise as sensing elements in diagnostic and sequencing applications. However …
great promise as sensing elements in diagnostic and sequencing applications. However …
Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges
Cytokines are signaling molecules between cells in immune system. Cytokine storm, due to
the sudden acute increase in levels of pro‐inflammatory circulating cytokines, can result in …
the sudden acute increase in levels of pro‐inflammatory circulating cytokines, can result in …
Electronic and electrochemical viral detection for point-of-care use: A systematic review
Detecting viruses, which have significant impact on health and the economy, is essential for
controlling and combating viral infections. In recent years there has been a focus towards …
controlling and combating viral infections. In recent years there has been a focus towards …
Precise DNA concentration measurements with nanopores by controlled counting
Using a solid-state nanopore to measure the concentration of clinically relevant target
analytes, such as proteins or specific DNA sequences, is a major goal of nanopore research …
analytes, such as proteins or specific DNA sequences, is a major goal of nanopore research …
Flossing DNA in a dual nanopore device
Solid‐state nanopores are a single‐molecule technique that can provide access to
biomolecular information that is otherwise masked by ensemble averaging. A promising …
biomolecular information that is otherwise masked by ensemble averaging. A promising …