Bacterial antagonism in host-associated microbial communities

L García-Bayona, LE Comstock - Science, 2018 - science.org
BACKGROUND Microbial communities are ubiquitous on Earth. The microbiota of different
habitats are diverse and have distinct functional traits, but there are common ecological …

Commensal inter-bacterial interactions sha** the microbiota

L Kern, SK Abdeen, AA Kolodziejczyk… - Current opinion in …, 2021 - Elsevier
The gut microbiota, a complex ecosystem of microorganisms of different kingdoms, impacts
host physiology and disease. Within this ecosystem, inter-bacterial interactions and their …

The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology

TE Wood, SA Howard, A Förster, LM Nolan, E Manoli… - Cell reports, 2019 - cell.com
The type VI secretion system (T6SS) is crucial in interbacterial competition and is a virulence
determinant of many Gram-negative bacteria. Several T6SS effectors are covalently fused to …

Polymorphic toxins and their immunity proteins: diversity, evolution, and mechanisms of delivery

ZC Ruhe, DA Low, CS Hayes - Annual review of microbiology, 2020 - annualreviews.org
All bacteria must compete for growth niches and other limited environmental resources.
These existential battles are waged at several levels, but one common strategy entails the …

Programmed secretion arrest and receptor-triggered toxin export during antibacterial contact-dependent growth inhibition

ZC Ruhe, P Subramanian, K Song, JY Nguyen… - Cell, 2018 - cell.com
Contact-dependent growth inhibition (CDI) entails receptor-mediated delivery of CdiA-
derived toxins into Gram-negative target bacteria. Using electron cryotomography, we show …

Phage infection and sub-lethal antibiotic exposure mediate Enterococcus faecalis type VII secretion system dependent inhibition of bystander bacteria

A Chatterjee, JLE Willett, GM Dunny, BA Duerkop - PLoS genetics, 2021 - journals.plos.org
Bacteriophages (phages) are being considered as alternative therapeutics for the treatment
of multidrug resistant bacterial infections. Considering phages have narrow host-ranges, it is …

Acinetobacter: an emerging pathogen with a versatile secretome

NM Elhosseiny, AS Attia - Emerging microbes & infections, 2018 - Taylor & Francis
Acinetobacter baumannii is a notorious pathogen that has emerged as a healthcare
nightmare in recent years because it causes serious infections that are associated with high …

Uncovering the Secretion Systems of Acinetobacter baumannii: Structures and Functions in Pathogenicity and Antibiotic Resistance

P Li, S Zhang, J Wang, MM Al-Shamiri, B Han, Y Chen… - Antibiotics, 2023 - mdpi.com
Infections led by Acinetobacter baumannii strains are of great concern in healthcare
environments due to the strong ability of the bacteria to spread through different apparatuses …

Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition

TM Halvorsen, KA Schroeder, AM Jones… - PLoS …, 2024 - journals.plos.org
Contact-dependent growth inhibition (CDI) is a widespread form of inter-bacterial
competition mediated by CdiA effector proteins. CdiA is presented on the inhibitor cell …

Effectiveness of Pseudomonas aeruginosa type VI secretion system relies on toxin potency and type IV pili-dependent interaction

M Rudzite, S Subramoni, RG Endres, A Filloux - PLoS Pathogens, 2023 - journals.plos.org
The type VI secretion system (T6SS) is an antibacterial weapon that is used by numerous
Gram-negative bacteria to gain competitive advantage by injecting toxins into adjacent prey …