Role of platelet-derived growth factors in physiology and medicine

J Andrae, R Gallini, C Betsholtz - Genes & development, 2008 - genesdev.cshlp.org
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …

The biology of platelet-derived growth factor

R Ross, EW Raines, DF Bowen-Pope - Cell, 1986 - Elsevier
Cell proliferation and directed cell movement are key events in several normal processes
including embryogenesis and development, responses to injury such as wound repair, and …

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product …

DM Bradham, A Igarashi, RL Potter… - The Journal of cell …, 1991 - rupress.org
Human umbilical vein endothelial (HUVE) cells have been previously reported to express
the genes for the A and B chains of PDGF and to secrete PDGF-related factors into culture …

Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin

N Ling, SY Ying, N Ueno, S Shimasaki, F Esch, M Hotta… - Nature, 1986 - nature.com
Inhibin is a gonadal protein that specifically inhibits the secretion of pituitary follicle-
stimulating hormone (FSH). Two forms of inhibin (A and B) have been purified from porcine …

[HTML][HTML] Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

PV Hauschka, AE Mavrakos, MD Iafrati… - Journal of Biological …, 1986 - Elsevier
The mineralized matrix of osseous tissue harbors abundant mitogenic activity which is
extractable by demineralizing solvents. In bovine bone powder free of blood and cartilage …

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine …

M Hermanson, K Funa, M Hartman, L Claesson-Welsh… - Cancer research, 1992 - AACR
The expression of platelet-derived growth factor (PDGF) and its receptors was analyzed in
14 gliomas of various degrees of malignancy and compared with three gliosis cases by in …

A role for platelet-derived growth factor in normal gliogenesis in the central nervous system

WD Richardson, N Pringle, MJ Mosley, B Westermark… - Cell, 1988 - cell.com
The bipotential progenitor cells (O-2A progenitors) that produce oligodendrocytes and type-
2 astrocytes in the develo** rat optic nerve are induced to proliferate in culture by type* 1 …

Early signals in the mitogenic response

E Rozengurt - Science, 1986 - science.org
Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents
acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals …

[PDF][PDF] Growth factors and the regulation of bone remodeling.

E Canalis, T McCarthy… - The Journal of clinical …, 1988 - Am Soc Clin Investig
Perspectives Page 1 Perspectives Growth Factors and the Regulation of Bone Remodeling
Ernesto Canalis, Thomas McCarthy, and Michael Centrella Department ofMedicine (Endocrine …

Development and characterization of a conditionally immortalized human fetal osteoblastic cell line

SA Harris, RJ Enger, LB Riggs… - Journal of Bone and …, 1995 - Wiley Online Library
We report the establishment of a human fetal osteoblast cell line derived from biopsies
obtained from a spontaneous miscarriage. Primary cultures isolated from fetal tissue were …