The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …

Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …

The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

In the last few years, increased attention has been focused on a class of organisms called
psychrophiles. These organisms, hosts of permanently cold habitats, often display metabolic …

Intermediate filaments (IFs) are major constituents of the cytoskeleton and nuclear boundary
in animal cells. They are of prime importance for the functional organization of structural …

Microtubules are the basic components of cell structure, which take part in a wide number of
pivotal cellular functions. Drugs that are able to modulate the microtubule assembly either by …

Anticancer agents that interfere with microtubulin function are in widespread use in man and
have a broad spectrum of activity against both hematological malignancies and solid tumors …

How TaxoI@ stabilises microtubule structure Page 1 Minireview R65 How TaxoI@ stabilises
microtubule structure Linda A Amos and Jan Lijwe The structure of tubulin shows paclitaxel …

The vinca alkaloids have been used in the treatment of cancer for over 40 years. Their
efficacy has ensured that they remain among the drugs of choice for a number of human …

The development of resistance to paclitaxel in tumors is one of the most significant obstacles
to successful therapy. Overexpression of the βIII-tubulin isotype has been associated with …