Neuroinflammation is a complex biological process that plays a significant role in various
brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory …

The ability to reprogram patient-derived-somatic cells to IPSCs (Induced Pluripotent Stem
Cells) has led to a better understanding of aging and age-related diseases like Parkinson's …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive motor neuron loss, with additional pathophysiological involvement of non …

Neuronal cells are highly functioning but also extremely stress-sensitive cells. By defending
the neuronal cells against pathogenic insults, microglial cells, a unique cell type, act as the …

Progress in stem cell research has revolutionized the medical field for more than two
decades. More recently, the discovery of induced pluripotent stem cells (iPSCs) has allowed …

Background The development of induced pluripotent stem cells (iPSCs) technology has
enabled human cellular disease modeling for inaccessible cell types, such as neural cells in …

N-methyl-D-aspartate receptors (NMDARs) are critical components of the mammalian
central nervous system, involved in synaptic transmission, plasticity, and neurodevelopment …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder, characterized
by progressive loss of both upper and lower motor neurons, resulting in clinical features …

Neuronal hyperexcitability is a hallmark of epilepsy. It has been recently shown in rodent
models of seizures that microglia, the brain's resident immune cells, can respond to and …

Accumulation of cytoplasmic inclusions of TAR-DNA binding protein 43 (TDP-43) is seen in
both neurons and glia in a range of neurodegenerative disorders, including amyotrophic …