Although astrogliosis and microglia activation are characteristic features of multiple sclerosis
(MS) and other central nervous system (CNS) lesions the exact functions of these events are …

The central nervous system (CNS) is immune privileged with access to leukocytes being
limited. In several neurological diseases, however, infiltration of immune cells from the …

Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a
copper chelator, is widely used to study demyelination and remyelination in the CNS, in the …

The declining efficiency of myelin regeneration in individuals with multiple sclerosis has
stimulated a search for ways by which it might be therapeutically enhanced. Here we have …

The copper chelator cuprizone (bis-cyclohexanone oxaldihydrazone) was established as a
neurotoxin in rodents in 1966 by Carlton. During the following years the usefulness of …

Multiple sclerosis is a chronic demyelinating disease of the central nervous system.
Spontaneous remyelination during early disease stages is thought to preserve and partially …

The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic
lateral sclerosis has been intensively studied. However, the origin of these disorders …

In multiple sclerosis (MS), gray matter pathology is characterized by less pronounced
inflammation when compared with white matter lesions. Although regional differences in the …

The feeding of cuprizone (CPZ) to animals has been extensively used to model the
processes of demyelination and remyelination, with many papers adopting a narrative linked …

Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple
sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular …