Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded
by PTPN11), promotes developmental disorders and several malignancies by varying …

Histone acetylation regulates many cellular processes, and specific acetylation marks, either
singly or in combination, produce distinct outcomes. For example, the acetylation pattern on …

A large fraction of the mammalian genome is organized into inactive chromosomal domains
along the nuclear lamina. The mechanism by which these lamina associated domains …

LSD1 is a recently identified human lysine (K)-specific histone demethylase. LSD1 is
associated with HDAC1/2; CoREST, a SANT domain-containing corepressor; and BHC80, a …

We have previously described a multiprotein complex termed the BHC or BRAF–HDAC
complex, which is required for the repression of neuronal-specific genes. We have shown …

Cell-type-specific gene expression is physiologically modulated by the binding of
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …

Transcription regulation through chromatin compaction and decompaction is regulated
through various chromatin-remodeling complexes such as nucleosome remodeling and …

Chromatin-remodelling complexes have an important role in all DNA-mediated processes
and, although much is known about how these enzymes regulate chromosomal DNA …