In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …

Acute myocardial infarction is a major cause of death worldwide. The most important therapy
for limiting ischemic injury and infarct size is timely and efficient myocardial reperfusion …

The field of non-coding RNA (ncRNA) has expanded over the last decade following the
discoveries of several new classes of regulatory ncRNA. A growing amount of evidence now …

Long noncoding RNAs (lncRNAs) play important regulatory roles in cellular physiology. The
contributions of lncRNAs to ischemic heart disease remain largely unknown. The aim of this …

NF-κB is a well-known transcription factor that is intimately involved with inflammation and
immunity. We have previously shown that NF-κB promotes inflammatory events and …

Diabetes accelerates saphenous vein grafts calcification after years of coronary artery
bypass grafting (CABG) surgery. Vascular smooth muscle cells (VSMC) undergoing a …

Cardiovascular diseases are a leading cause of death for adults worldwide. Published
articles have shown that toll-like receptor 4 (TLR4), a member of the toll-like receptor (TLR) …

Heat shock protein 70 (Hsp70) is well documented to possess general cytoprotective
properties in protecting the cell against stressful and noxious stimuli. We have recently …

Background/Objectives: Aging is associated with structural and functional changes in the
heart, including hypertrophy, fibrosis, and impaired contractility. Cellular mechanisms such …