Metabolomics 20 years on: what have we learned and what hurdles remain?

S Alseekh, AR Fernie - The Plant Journal, 2018 - Wiley Online Library
The term metabolome was coined in 1998, by analogy to genome, transcriptome and
proteome. The first research papers using the terms metabolomics, metabonomics …

Metabolomics for functional genomics, systems biology, and biotechnology

K Saito, F Matsuda - Annual review of plant biology, 2010 - annualreviews.org
Metabolomics now plays a significant role in fundamental plant biology and applied
biotechnology. Plants collectively produce a huge array of chemicals, far more than are …

Gas chromatography mass spectrometry–based metabolite profiling in plants

J Lisec, N Schauer, J Kopka, L Willmitzer, AR Fernie - Nature protocols, 2006 - nature.com
The concept of metabolite profiling has been around for decades, but technical innovations
are now enabling it to be carried out on a large scale with respect to the number of both …

Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models

S Wiklund, E Johansson, L Sjöström… - Analytical …, 2008 - ACS Publications
Metabolomics studies generate increasingly complex data tables, which are hard to
summarize and visualize without appropriate tools. The use of chemometrics tools, eg …

Metabolomic analysis in food science: a review

JM Cevallos-Cevallos, JI Reyes-De-Corcuera… - Trends in Food Science …, 2009 - Elsevier
Metabolomics has emerged as an important tool in many disciplines such as human
diseases and nutrition, drug discovery, plant physiology and others. In food science …

Statistical strategies for avoiding false discoveries in metabolomics and related experiments

DI Broadhurst, DB Kell - Metabolomics, 2006 - Springer
Many metabolomics, and other high-content or high-throughput, experiments are set up
such that the primary aim is the discovery of biomarker metabolites that can discriminate …

Potato glycoalkaloids and metabolites: roles in the plant and in the diet

M Friedman - Journal of agricultural and food chemistry, 2006 - ACS Publications
Potatoes, members of the Solanaceae plant family, serve as major, inexpensive low-fat food
sources providing energy (starch), high-quality protein, fiber, and vitamins. Potatoes also …

Foodomics: MS‐based strategies in modern food science and nutrition

M Herrero, C Simó, V García‐Cañas… - Mass spectrometry …, 2012 - Wiley Online Library
Modern research in food science and nutrition is moving from classical methodologies to
advanced analytical strategies in which MS‐based techniques play a crucial role. In this …

Current metabolomics: practical applications

SP Putri, Y Nakayama, F Matsuda, T Uchikata… - Journal of bioscience …, 2013 - Elsevier
The field of metabolomics continues to grow rapidly over the last decade and has been
proven to be a powerful technology in predicting and explaining complex phenotypes in …

Plant metabolomics: from holistic hope, to hype, to hot topic

RD Hall - New phytologist, 2006 - Wiley Online Library
In a short time, plant metabolomics has gone from being just an ambitious concept to being
a rapidly growing, valuable technology applied in the stride to gain a more global picture of …